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KMID : 0613820160260111308
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Journal of Life Science
2016 Volume.26 No. 11 p.1308 ~ p.1312
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Effects of Transition Metal Gallium on the Serum Biochemistry and Erythrocyte Morphology of Goldfish (Carassius auratus)
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Kim Dong-Hwi
Subramanian Dharaneedharan
Jang Young-Hwan
Park So-Hyun
Heo Moon-Soo
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Abstract
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Heavy metals such as gallium (Ga) cause serious physiological damage to exposed organisms, mostly of aquatic species. Ga one of the inter-metallic, transition elements increasingly being used in making high-speed semiconductors, such as Ga arsenide. The purposes of this study were to investigate the effects of Ga on acute toxicity, serum biochemical changes, and erythrocyte morphological changes in the blood stream of goldfish (Carassius auratus). Median lethal concentrations were determined in acute tests. The 96 hr LC50 value was 9.15 mg/ml. Goldfish were exposed to different Ga concentrations (2.0, 4.0, and 8.0 mg/ml) for 30 days to assess its toxic effects. The results indicate that the measured serum biochemistry parameters (including glucose, blood urea nitrogen, creatinine, cholesterol, and triglyceride) of the Ga-exposed fish groups differed significantly from the untreated fish group. In addition, a change in the erythrocytes’ morphology at a high concentration (8.0 mg/ml) of Ga exposure shows respiratory problems. Our results suggest that 2.0 mg/ml is proposed as a biologically safe concentration that can be used for establishing tentative water quality criteria concerning the same-size goldfish.
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KEYWORD
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Erythrocyte, gallium, goldfish, LC50, serum biochemistry
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